采用气相色谱-质谱联用仪选择离子监测模式测定血浆中的白消安。
Determination of busulfan in plasma by GC-MS with selected-ion monitoring.
作者信息
Ehrsson H, Hassan M
出版信息
J Pharm Sci. 1983 Oct;72(10):1203-5. doi: 10.1002/jps.2600721024.
PMID:6644573
Abstract
A GC-MS technique with selected-ion monitoring is described for the determination of busulfan in plasma. Busulfan is extracted from plasma with methylene chloride and converted to 1,4-diiodobutane. Analysis by GC-MS with selected-ion monitoring (m/z 183) gave a relative standard deviation of +/- 4.3% (n = 5) at the 10-ng/ml level.
摘要
描述了一种采用选择离子监测的气相色谱-质谱联用（GC-MS）技术测定血浆中白消安的方法。白消安用二氯甲烷从血浆中萃取出来并转化为1,4-二碘丁烷。通过选择离子监测（m/z 183）的GC-MS分析，在10 ng/ml水平下相对标准偏差为±4.3%（n = 5）。
Zotero 插件