Frank S G, Kavaliunas D R
J Pharm Sci. 1983 Oct;72(10):1215-7. doi: 10.1002/jps.2600721028.
The formation of an inclusion compound by beta-cyclodextrin with hydrocortisone has been studied by proton magnetic resonance (1H-NMR) and phase solubility analysis. The magnitude of the chemical shifts of the interior and exterior beta-cyclodextrin protons in the presence of hydrocortisone indicated that hydrocortisone is included within the beta-cyclodextrin cavity and probably interacts with protons on the edge of the torus. The overall stoichiometry of the inclusion compound was not a single, simple relationship, but was unusual in that it was variable and apparently dependent on the relative amounts of hydrocortisone and beta-cyclodextrin in the system.
通过质子磁共振（1H-NMR）和相溶解度分析研究了β-环糊精与氢化可的松形成包合物的情况。在氢化可的松存在下，β-环糊精内部和外部质子的化学位移大小表明氢化可的松被包含在β-环糊精腔内，并且可能与环面边缘的质子相互作用。包合物的整体化学计量关系不是单一、简单的关系，而是不同寻常的，因为它是可变的，并且显然取决于系统中氢化可的松和β-环糊精的相对量。
