Atabekova G A, Koshcheenko N N, Romantsev E F
Vopr Med Khim. 1978 May-Jun;24(3):401-4.
Concentration of ATP in thymus, spleen, blood and liver tissues of intact rats constituted 84.6 +/- 9.3, 62.3 +/- 12.8, 18.7 +/- 3.9 and 103 +/- 23.8 mg% per 1 g of tissue, respectively. Intramuscular administration of ATP at a dose 350 mg/kg caused wave-shaped alterations in ATP content in rat spleen and liver tissues. Concentration of the nucleotide tend to increase in blood within the period of examination (4 days). Alterations observed in the pool of ATP in tissues studied appear to be due to the effect of the dephosphorylation products of the ATP administered (adenosine, probably) on intracellular metabolism of adenylicnucleotides, particularly, on the metabolism of ATP.
完整大鼠胸腺、脾脏、血液和肝脏组织中ATP的浓度分别为每1克组织84.6±9.3、62.3±12.8、18.7±3.9和103±23.8毫克%。以350毫克/千克的剂量肌肉注射ATP会导致大鼠脾脏和肝脏组织中ATP含量呈波浪形变化。在检查期间（4天），血液中该核苷酸的浓度趋于增加。在所研究的组织中观察到的ATP池变化似乎是由于所注射ATP的去磷酸化产物（可能是腺苷）对腺苷酸核苷酸的细胞内代谢，特别是对ATP代谢的影响。
