[异烟肼对结核病患者转氨酶活性影响的新方面]
[New aspects of the effect of isoniazid on transaminase activity in tuberculosis].
作者信息
Sodikov E S, Kazakov K S
出版信息
Vopr Med Khim. 1978 Jan-Feb;24(1):3-7.
New evidence is obtained for inhibitory effect of isoniazid on activity of transaminases in prolonged application of the drug. Increase in the isoniazid inhibitory effect on alanine aminotransferase activity was shown to correlate with elevated concentration of Cu2+ in blood serum arising in experimental tuberculosis. Cu2+ and Co2+ caused the increase in the inhibitory effect of isoniazid due to their incorporation into structure of the preparation. The microelements, combined with pyridoxine, inhibited alanine aminotransferase and vice versa activated aspartate aminotransferase.
有新证据表明，长期使用异烟肼会对转氨酶活性产生抑制作用。结果显示，异烟肼对丙氨酸转氨酶活性抑制作用的增强与实验性结核病患者血清中铜离子浓度升高相关。铜离子和钴离子因掺入制剂结构而导致异烟肼抑制作用增强。这些微量元素与吡哆醇结合后，会抑制丙氨酸转氨酶，反之则会激活天冬氨酸转氨酶。
Zotero 插件