Heney N M, Ahmed S, Flanagan M J, Frable W, Corder M P, Hafermann M D, Hawkins I R
J Urol. 1983 Dec;130(6):1083-6. doi: 10.1016/s0022-5347(17)51695-x.
The tumors in 249 patients presenting initially with stages Ta and T1 bladder cancer were analyzed for tumor progression and recurrence. Only transurethral resection and/or fulguration was used before the first recurrence. Patients who received intravesical chemotherapy after the first tumor recurrence were excluded from an analysis of progression. Progression according to stages Ta and T1, and grades I, II and III was 4, 30, 2, 11 and 45 per cent, respectively. All differences were statistically significant. Progression also correlated with nontumor dysplasia and size. High tumor grade, lamina propria invasion, atypia elsewhere in the bladder, positive urinary cytology, tumor multiplicity and large tumors were associated with shorter intervals free of disease.
对249例最初表现为Ta期和T1期膀胱癌的患者的肿瘤进行了肿瘤进展和复发分析。首次复发前仅采用经尿道切除术和/或电灼术。首次肿瘤复发后接受膀胱内化疗的患者被排除在进展分析之外。根据Ta期和T1期以及I、II和III级的进展率分别为4%、30%、2%、11%和45%。所有差异均具有统计学意义。进展还与非肿瘤发育异常和大小相关。高肿瘤分级、固有层浸润、膀胱其他部位的异型性、尿细胞学阳性、肿瘤多发和大肿瘤与无病间隔时间较短有关。
