Viola F, Caputo O, Balliano G, Delprino L, Cattel L
J Steroid Biochem. 1983 Oct;19(4):1451-8. doi: 10.1016/0022-4731(83)91120-2.
The Aspergillus aureofulgens ability to cleave the side chain of progesterone (I) and the related C-21 steroids was studied. The enzymic system responsible for the progesterone side chain degradation was demonstrated to be adaptative and to operate by a Baeyer-Villiger mechanism. The cleavage of the side chain of the progesterone and of the related compounds was followed by the stereospecific reduction of the formed androst-4-ene-3,17-dione(II) to the 5 beta-androstan derivatives. Both the oxygenase and reductase activities seemed to be influenced by the growth conditions. Several steroids bearing different skeleton functions and different side chains were also tested in order to correlate the chemical structure with the microbial activity.
研究了金黄色曲霉裂解孕酮（I）及相关C-21甾体侧链的能力。负责孕酮侧链降解的酶系统被证明是适应性的，且通过拜耳-维利格机制起作用。孕酮及相关化合物侧链的裂解之后是将生成的雄甾-4-烯-3,17-二酮（II）立体定向还原为5β-雄甾烷衍生物。加氧酶和还原酶活性似乎都受生长条件影响。还测试了几种具有不同骨架功能和不同侧链的甾体，以便将化学结构与微生物活性相关联。
