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[从天花疫苗中分离出的噬菌体]

[Bacteriophages isolated from smallpox vaccine].

作者信息

Dzagurov S G, Peremitina L D, Iaroslavskaia N V, Malysheva V F, Berillo E A

出版信息

Vopr Virusol. 1978 Mar-Apr(2):220-5.

PMID:664622
Abstract

A number of lots of dermal and tissue culture smallpox vaccine was studied for the presence of bacteriophage. The presence of bacteriophage was established in lots of tissue culture vaccine but not in the dermal vaccine. Bacteriophage was detected by a modified method for phage isolation. The concentration and activity of the isolated bacteriophage were low. Its activity was increased by passages. The bacteriophage was stable and lysed the main serotypes of enteropathogenic E. coli as well as strains of Shigella sonnei and Salmonella of typhoid A.

摘要

对多个批次的皮肤用和组织培养用天花疫苗进行了噬菌体检测。在多个批次的组织培养疫苗中发现了噬菌体,但在皮肤用疫苗中未发现。通过一种改良的噬菌体分离方法检测到了噬菌体。分离出的噬菌体浓度和活性较低。通过传代其活性有所提高。该噬菌体很稳定,可裂解肠道致病性大肠杆菌的主要血清型以及宋内志贺氏菌和甲型伤寒沙门氏菌菌株。

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