Login I S, Thorner M O, MacLeod R M
Neuroendocrinology. 1983 Nov;37(5):317-20. doi: 10.1159/000123568.
We studied the in vitro influence of physiologically relevant zinc concentrations on the pituitary synthesis and secretion of prolactin (Prl). Zinc in concentrations between 1 and 10 microM reduced Prl secretion and, to a milder extent, synthesis, but not basal or stimulated growth hormone (GH) or LH release. At a supraphysiological concentration of 100 microM, zinc markedly decreased Prl synthesis and secretion, but increased LH secretion. The ability of a physiological zinc concentration to influence Prl secretion suggests that this trace element may have a role in the in vivo regulation of Prl release.
我们研究了生理相关锌浓度对垂体催乳素（Prl）合成和分泌的体外影响。浓度在1至10微摩尔之间的锌可降低Prl分泌，并在较轻程度上降低其合成，但不影响基础或刺激状态下的生长激素（GH）或促黄体生成素（LH）释放。在100微摩尔的超生理浓度下，锌显著降低Prl合成和分泌，但增加LH分泌。生理浓度的锌影响Prl分泌的能力表明，这种微量元素可能在体内Prl释放的调节中发挥作用。
