Montuori R, Antinolfi I, Fasanaro A, Ferrara F, Matera C, Prossomariti L, Rametta V, Stabile P
Minerva Med. 1983 Oct 27;74(41):2465-70.
A case of a 55 years old woman suffering from multiple myeloma with strong bone marrow proplasmocytic infiltration, several osteolytic and osteoporotic lesions and high seric M-component level and hypertensive heart failure is described. After 32 months of partial remission obtained with cyclic chemotherapy, large cutaneous tumors arose. Despite of a new therapeutic trial, in the last 8 months, an increase of bone marrow and seric signs was observed without involvement of the lungs or kidneys or expression of plasma-cell leukemia. Death occurred at 50th month because of sepsis and heart failure. A real cutaneous tropism, late occurred and without cytohistological changes, is stressed. The meaning of the rich vascularization of the skin over the tumors in absence of inflammation and necrosis remains unclear.
描述了一例55岁女性，患有多发性骨髓瘤，伴有强烈的骨髓原浆细胞浸润、多处溶骨性和骨质疏松性病变、高血清M蛋白水平以及高血压性心力衰竭。在接受周期性化疗获得32个月的部分缓解后，出现了巨大的皮肤肿瘤。尽管进行了新的治疗试验，但在最后8个月，观察到骨髓和血清指标增加，未累及肺部或肾脏，也无浆细胞白血病表现。患者在第50个月因败血症和心力衰竭死亡。强调了一种真正的皮肤嗜性，发生较晚且无细胞组织学改变。肿瘤上方皮肤丰富血管化在无炎症和坏死情况下的意义仍不清楚。
