Nishikawa T, Takashima M, Toru M
Neurosci Lett. 1983 Oct 10;40(3):245-50. doi: 10.1016/0304-3940(83)90046-0.
[3H]Kainic acid binding sites were measured post mortem in the putamen and prefrontal cortex areas from 10 control subjects and 12 schizophrenic patients. A 25-50% increase in [3H]kainic acid binding was observed in the medial frontal (Brodmann areas 9, 10 and 46) and eye-movement areas (8), but not in the other regions of schizophrenic brains. No significant correlation between the binding and either age at death, storage of the brains, duration of illness or neuroleptics-free period was observed. These findings suggest that a dysfunction of cortical excitatory amino acidergic transmission may be involved in schizophrenia.
在死后对10名对照受试者和12名精神分裂症患者的壳核和前额叶皮质区域进行了[3H]海藻酸结合位点测定。在额叶内侧（布罗德曼区9、10和46）和眼球运动区（8）观察到[3H]海藻酸结合增加了25 - 50%，但在精神分裂症患者大脑的其他区域未观察到这种增加。未观察到结合与死亡年龄、大脑保存情况、病程或无抗精神病药物治疗期之间存在显著相关性。这些发现表明，皮质兴奋性氨基酸能传递功能障碍可能与精神分裂症有关。
