由纯音产生的音频定位带在注射2-脱氧葡萄糖后很久才开始出现。

Tonotopic bands produced by tones commenced long after 2-deoxyglucose injection.

作者信息

Webster W R, Servière J, Martin R, Hartley E

出版信息

Neurosci Lett. 1983 Oct 10;40(3):281-6. doi: 10.1016/0304-3940(83)90052-6.

Abstract

Presentation of two different tones at two different time periods each under two different types (14C or 3H) of 2-deoxyglucose (2-DG) produced two bands of labelling in the inferior colliculus (IC) of a guinea pig. Filtering tests revealed that both bands were produced by only one of the labels (14C). Four guinea pigs were given one injection of 2-DG and then stimulated with two tones, each presented at different time periods. Two bands of labelling were produced in IC, with one band being produced by tones given 55-90 min after injection. The implications of this long lasting effect of 2-DG are discussed for the general 2-DG model and for sequential double labelling experiments.

摘要

在豚鼠的下丘（IC）中，在两个不同时间段分别以两种不同类型（14C或3H）的2-脱氧葡萄糖（2-DG）呈现两种不同音调，产生了两条标记带。过滤测试显示，两条带均仅由其中一种标记（14C）产生。给四只豚鼠注射一次2-DG，然后用两种音调刺激，每种音调在不同时间段呈现。在IC中产生了两条标记带，其中一条带是由注射后55-90分钟给予的音调产生的。针对一般的2-DG模型和顺序双标记实验，讨论了2-DG这种长效作用的意义。