Gallo J H, Young G A, Forrest P R, Vincent P C, Jennis F
Pathology. 1983 Jul;15(3):241-5. doi: 10.3109/00313028309083500.
The clinical features are described of disseminated atypical mycobacterial infection of the subcutaneous tissues occurring in a patient 3 yr after the diagnosis of hairy cell leukemia. Skin biopsy identified the causative organism as an atypical mycobacterium of the M. avium-intracellulare-scrofulaceum (MAIS) complex. In vitro studies showed that the patient had impaired mononuclear cell phagocytosis. These findings, lend support to the hypothesis of a specific defect of immunity in hairy cell leukemia.
本文描述了一例毛细胞白血病诊断3年后发生的皮下组织播散性非典型分枝杆菌感染的临床特征。皮肤活检确定病原体为鸟分枝杆菌-胞内分枝杆菌-瘰疬分枝杆菌(MAIS)复合群中的非典型分枝杆菌。体外研究表明,该患者单核细胞吞噬功能受损。这些发现支持了毛细胞白血病存在特异性免疫缺陷的假说。