Mattison D R, Shiromizu K, Pendergrass J A, Thorgeirsson S S
Pediatr Pharmacol (New York). 1983;3(1):49-55.
Ovarian reduced glutathione concentration (microgram/mg wet ovarian weight) develops from levels of less than 0.2 microgram/mg in newborn Osborn Mendel rats to plateau at 0.7 microgram/mg between the ages of 3-7 weeks of age, finally reaching mature levels of approximately 1.0 microgram/mg between 7-8 weeks of age. Ovarian reduced glutathione concentration matures somewhat faster in Sprague Dawley rats, reaching mature levels of 1.0 microgram/mg between 4-6 weeks of age. The development of ovarian glutathione from immature (less than 0.2 microgram/mg) to mature levels (1.0 microgram/mg) was also observed over similar developmental time spans in DBA/2N and C57BL/6N mice. The sensitivity of primordial oocytes to destruction by cyclophosphamide in C57BL/6N mice was considerably different at 4 and 6 weeks of age. The ED50 for primordial oocyte destruction at 4 weeks of age in C57BL/6N mice was 140 mg/kg while at 6 weeks of age the ED50 was 260 mg/kg. The increase in ovarian reduced glutathione with age and the increasing resistance to primordial oocyte destruction over the same time period are consistent with the hypothesis that glutathione plays a major role in the modulation of primordial oocyte destruction.
新生奥斯本·孟德尔大鼠卵巢中还原型谷胱甘肽浓度（微克/毫克湿卵巢重量）从低于0.2微克/毫克的水平发展而来，在3至7周龄时达到0.7微克/毫克的稳定水平，最终在7至8周龄时达到约1.0微克/毫克的成熟水平。在斯普拉格·道利大鼠中，卵巢还原型谷胱甘肽浓度成熟得稍快一些，在4至6周龄时达到1.0微克/毫克的成熟水平。在DBA/2N和C57BL/6N小鼠的相似发育时间段内，也观察到卵巢谷胱甘肽从不成熟水平（低于0.2微克/毫克）发展到成熟水平（1.0微克/毫克）。C57BL/6N小鼠中原始卵母细胞对环磷酰胺破坏的敏感性在4周龄和6周龄时有很大差异。C57BL/6N小鼠4周龄时原始卵母细胞破坏的半数有效剂量（ED50）为140毫克/千克，而6周龄时ED50为260毫克/千克。卵巢还原型谷胱甘肽随年龄增加以及同一时期对原始卵母细胞破坏的抵抗力增加，这与谷胱甘肽在调节原始卵母细胞破坏中起主要作用的假设一致。
