König P, Küfferle B, Lenz G
Wien Klin Wochenschr. 1978 May 26;90(11):380-2.
A case is presented of lithium intoxication with therapeutic doses of lithium, owing to the additional administration of a sodium-excreting diuretic. Since the patient was receiving neuroleptic therapy at the same time, intoxication symptoms at the onset were falsely attributed to neuroleptic extrapyramidal effects. The possible effects of widely-used diuretics in conjunction with lithium therapy are presented. The combination of both therapeutic substances is possible, but calls for extreme caution and strict control of medication, diet and serum lithium levels.
本文报告一例因额外使用排钠利尿剂导致治疗剂量锂中毒的病例。由于该患者同时接受抗精神病药物治疗,起病时的中毒症状被错误地归因于抗精神病药物的锥体外系效应。文中介绍了广泛使用的利尿剂与锂治疗联合使用时可能产生的影响。两种治疗药物联合使用是可行的,但需要极其谨慎,并严格控制用药、饮食和血清锂水平。