Fedotov V P, Ivanenko T I, Gudoshnikov V I, Bushueva G I, Batrameeva L A
Probl Endokrinol (Mosk). 1983 Sep-Oct;29(5):48-54.
When administered subcutaneously to male rats, the novel peptides retromet-enkephalin and retro-leu-enkephalin stimulated prolactin (PRL) release less powerfully than morphine but somewhat greater than met-enkephalin. Leu-enkephalin did not affect PRL secretion in vivo. Neither morphine nor any of opioid peptides under study were able to stimulate basal or the dopamine-inhibited PRL release from cultured adenohypophyseal cells of male rats. It is concluded that stimulatory effects of opiates and opioid peptides on PRL secretion in rats are mediated via the hypothalamus or some other neural structures.
当向雄性大鼠皮下注射时，新型肽类物质逆甲硫氨酸脑啡肽和逆亮氨酸脑啡肽刺激催乳素（PRL）释放的作用比吗啡弱，但比甲硫氨酸脑啡肽稍强。亮氨酸脑啡肽在体内不影响PRL分泌。吗啡和所研究的任何一种阿片肽均不能刺激雄性大鼠培养的腺垂体细胞的基础PRL释放或多巴胺抑制的PRL释放。结论是，阿片类药物和阿片肽对大鼠PRL分泌的刺激作用是通过下丘脑或其他一些神经结构介导的。
