Panchenko L V, Sergienko L Iu
Probl Endokrinol (Mosk). 1983 Sep-Oct;29(5):78-82.
A study was made of 5 alpha-reductase activity, transformation of 3H-testosterone to 3H-dihydrotestosterone in the liver, kidneys prostate an in the skin of the scrotum, as well as of the level of plasma testosterone in male Wistar rats at varying age periods of postnatal ontogenesis. The data obtained indicate that by the moment of birth the androgen-sensitive organs of male rats include functionally active 5 alpha-reductase. During body development, periods of the enzyme activation were discovered. It was shown that by senility androgen metabolism in the organs under study decelerates whereas, 5 alpha-dihydrotestosterone tends towards accumulation by the cells.
对雄性Wistar大鼠出生后个体发育不同时期的5α-还原酶活性、肝脏、肾脏、前列腺和阴囊皮肤中3H-睾酮向3H-双氢睾酮的转化以及血浆睾酮水平进行了研究。所获得的数据表明，在出生时，雄性大鼠的雄激素敏感器官中就存在功能活跃的5α-还原酶。在身体发育过程中，发现了该酶的激活期。结果表明，在衰老过程中，所研究器官中的雄激素代谢减缓，而5α-双氢睾酮则趋于在细胞中积累。
