Svojtková E, Deyl Z, Macek K, Adam M
Physiol Bohemoslov. 1983;32(5):449-59.
It has been shown that in the skin of chronically irradiated rats the proportion of collagen type III as compared to collagen type I is increased; on the other hand, no changes in the overall proportion to collagen were observed in the skin. It appears that the increased proportion of collagen type III in chronically irradiated rats is responsible for the decreased solubility of cutaneous collagen in these animals. Concomitantly, indirect evidence was accumulated for the presence of an additional cross-link in type III collagen, present only when irradiated animals served as the collagen source. This cross-link is located subterminally as long as it is not removed by limited pepsin digestion. It was concluded that the physiological decrease in solubility and the decrease in solubility observed in chronically irradiated animals have a different molecular background.
研究表明，在长期受辐射大鼠的皮肤中，与I型胶原蛋白相比，III型胶原蛋白的比例增加；另一方面，皮肤中胶原蛋白的总体比例未观察到变化。似乎长期受辐射大鼠中III型胶原蛋白比例的增加是这些动物皮肤胶原蛋白溶解度降低的原因。同时，积累了间接证据，表明仅在以受辐射动物作为胶原蛋白来源时才存在的III型胶原蛋白中存在一种额外的交联。只要这种交联未被有限的胃蛋白酶消化去除，它就位于亚末端。得出的结论是，生理上的溶解度降低和长期受辐射动物中观察到的溶解度降低具有不同的分子背景。
