Baker D G, Sager H, Constable W, Goodchild N
Radiat Res. 1983 Nov;96(2):367-73.
Areas of skin approximately 1.5 cm in diameter on the legs of mice were made hyperthermic (30 min at 42.7 degrees C) by exposure to an ultrasound beam (780 kHz), a single dose of X irradiation (2000 rad), or a combination of these treatments. After 35 days, when the acute reaction had reached a steady state, the same tissue was given a second treatment by either hyperthermia, irradiation, or a combination of hyperthermia and irradiation. When the first treatment was irradiation and the second treatment was either irradiation or a combination of hyperthermia and irradiation, the acute skin reactions were similar to those of skin not previously irradiated, indicating a large proportion of recovery from the first irradiation. When irradiation was the first treatment, a comparison of second treatments by hyperthermia plus irradiation with irradiation alone showed a thermal enhancement of 1.45. When the first treatment was hyperthermia plus irradiation, a comparison of second treatments by hyperthermia plus irradiation with irradiation also showed an enhancement factor of 1.45 for the combined treatment.
通过暴露于超声束（780千赫）、单次X射线照射（2000拉德）或这些治疗方法的组合，使小鼠腿部直径约1.5厘米的皮肤区域产生高温（42.7摄氏度下30分钟）。35天后，当急性反应达到稳定状态时，对同一组织进行第二次治疗，治疗方式为热疗、照射或热疗与照射的组合。当第一次治疗为照射，第二次治疗为照射或热疗与照射的组合时，急性皮肤反应与未预先照射的皮肤相似，表明从第一次照射中大部分得到恢复。当第一次治疗为照射时，比较热疗加照射的第二次治疗与单独照射，热增强系数为1.45。当第一次治疗为热疗加照射时，比较热疗加照射的第二次治疗与照射，联合治疗的增强系数也为1.45。
