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[苯并噻二唑衍生物辐射防护作用的分子机制]

[Molecular mechanisms of the radioprotective action of benzothiadiazole derivatives].

作者信息

Vladimirov V G, Mukhomorov V K, Strel'nikov Iu E, Tsepova N S, Kokushkina A V

出版信息

Radiobiologiia. 1983 Sep-Oct;23(5):616-9.

PMID:6647776
Abstract

The analysis was made of the relationship between the radioprotective efficiency of substituted benzothiadiazoles and their electronic characteristics. The protective effect of these substances was shown to correlate with their ability to participate in the electron transfer. It was established that the protective effect comes into play via the formation of metal complexes in which benzothiadiazole molecules are ligands. The protective effect increases with increasing energy of complex ligation and diffusion motility of the radioprotector molecules.

摘要

对取代苯并噻二唑的辐射防护效率与其电子特性之间的关系进行了分析。结果表明,这些物质的保护作用与其参与电子转移的能力相关。已确定保护作用是通过形成金属配合物来实现的,其中苯并噻二唑分子为配体。随着配合物连接能和辐射防护剂分子扩散运动性的增加,保护作用增强。

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