Lejeune F J, Jortay A M, Dor P
Recent Results Cancer Res. 1983;86:162-4. doi: 10.1007/978-3-642-82025-0_27.
Five inoperable invasive cases of malignant melanoma of the maxillofacial region were treated with seven intracarotid artery infusions of DTIC. Total doses of 3.5-9.5 g of DTIC were continuously administered for 15-25 days. Two of the five patients experienced transient objective regression after the first DTIC infusion but not after the second. Three patients were operated on after infusion and only one had recurrence. However, all patients died with disseminated disease within 3 years after DTIC infusion. Toxicity was encountered in two of seven infusions; it consisted in reversible leukopenia plus thrombopenia and leukopenia alone. These patients had received the highest doses, 9.5 g/25 days and 8 g/20 days respectively. It is concluded that intra-arterial infusion of DTIC can be temporarily effective in the polydisciplinary treatment of invasive head and neck melanomas.
对5例无法手术的颌面部恶性黑色素瘤侵袭性病例进行了7次动脉内输注氮烯咪胺（DTIC）治疗。DTIC总剂量为3.5 - 9.5克，连续给药15 - 25天。5例患者中有2例在首次输注DTIC后出现短暂的客观缓解，但第二次输注后未出现。3例患者在输注后接受了手术，只有1例复发。然而，所有患者在DTIC输注后3年内均因疾病播散而死亡。7次输注中有2次出现毒性反应；表现为可逆性白细胞减少加血小板减少以及单独的白细胞减少。这些患者接受了最高剂量，分别为9.5克/25天和8克/20天。结论是，动脉内输注DTIC在侵袭性头颈部黑色素瘤的多学科治疗中可暂时有效。
