The role of methylene blue infusion in the management of persistent or recurrent hyperparathyroidism.

Several reports have suggested that methylene blue be used for the selective staining of the parathyroid glands. To date, there have been no reports on the use of methylene blue in persistent or recurrent hyperparathyroidism. In 30 such cases, we found that the dye was safe and easy to administer and that the level of methemoglobinemia after infusion was insignificant. We suggest that the dye be used in all cases involving cervical or mediastinal (or both) reexploration for persistent or recurrent hyperparathyroidism.