Metz A, Madörin M, Petignat J, Deyssenroth H
Z Versuchstierkd. 1978;20(2):73-80.
Rats (OFA - Sandoz) were kept under barrier conditions their whole lives in order to study the correlations between food intake, body weight, serum cholesterol and mortality rate. The cholesterol levels in males in the first life-half rose in correlation to food intake and body weight increase. In the second half, however, the cholesterol level increased again, whereas body weight and food intake decreased. The mortality rate rose, which was correlated to the second increase of the cholesterol level and the body weight loss (probit analysis). These findings were not made in females, which had lower food intake, body weight and cholesterol levels.
为了研究食物摄入量、体重、血清胆固醇和死亡率之间的相关性，将大鼠（奥芬-山德士）在屏障条件下饲养一生。在生命的前半期，雄性大鼠的胆固醇水平随着食物摄入量和体重的增加而升高。然而，在生命的后半期，胆固醇水平再次升高，而体重和食物摄入量却下降了。死亡率上升，这与胆固醇水平的第二次升高和体重减轻有关（概率分析）。在食物摄入量、体重和胆固醇水平较低的雌性大鼠中未发现这些结果。
