Gromov P S, Val'iano N M, Akhunov V S, Annenkov G A
Vopr Med Khim. 1983 Sep-Oct;29(5):66-9.
Activity of dihydrohypteridine reductase, estimated by means of spectrophotometric method, was found in cell culture of human fibroblasts and in leukocytes of peripheric blood. The enzymatic activity was not altered markedly with time; thus suggesting a possibility to classify dihydropteridine reductase as a constitutive enzyme. In patients with typical form of phenylketonuria the enzymatic activity tended to decrease as compared with healthy persons.
采用分光光度法测定，发现二氢蝶啶还原酶活性存在于人类成纤维细胞的细胞培养物和外周血白细胞中。酶活性不会随时间显著改变；因此表明有可能将二氢蝶啶还原酶归类为组成酶。与健康人相比，典型苯丙酮尿症患者的酶活性往往会降低。
