Kalinina I A, Dikun P P
Vopr Onkol. 1983;29(11):92-7.
Benz(a)pyrene (BP) levels in extracts and solvent cake obtained by alcoholic and aqueous extraction of specimens of 20 different medicinal plants were measured to explore into the possibility of its passage from these plants to drugs. Seventy percent alcoholic extracts were found to contain 40-60% of BP passed from raw material, while aqueous extracts--2-3% (in some cases 10-14%). Maximal concentrations of BP in alcoholic extracts were 0.6-0.7 micrograms/1 and 0.03-0.04 micrograms/1--in aqueous ones. A significant correlation between BP level in extracts and its content in plants was established. BP pathways in the course of solasodine manufacturing from nightshade (Solanum lacinatum) were studied. As little as 1% of BP passed to extract after primary extraction in 2%--sulfuric acid. Solasodine contained about 3 micrograms/kg of BP.
测定了20种不同药用植物样本经乙醇和水提取后提取物及溶剂饼中的苯并(a)芘（BP）含量，以探究其从这些植物转移至药物中的可能性。发现70%的乙醇提取物含有从原材料转移来的40 - 60%的BP，而水提取物含2 - 3%（某些情况下为10 - 14%）。乙醇提取物中BP的最大浓度为0.6 - 0.7微克/1，水提取物中为0.03 - 0.04微克/1。提取物中BP含量与其在植物中的含量之间建立了显著相关性。研究了从茄属植物（刺茄）生产茄解定过程中的BP途径。在2%硫酸中进行一次提取后，仅有1%的BP转移至提取物中。茄解定含约3微克/千克的BP。
