Kiriakov A, Malamov E, Apostolova Iu, Tsenov I, Tinterova Z
Vutr Boles. 1983;22(3):74-81.
The effect of one-month bezalip (600 mg daily) outpatient department treatment was studied on serum lipids and lipoproteins of 34 patients (31 males and 3 females), aged from 30 to 60 with various types primary HLP (IIA, IIB, IV and V). After the treatment, it was established that tendency to malization of the increased concentrations of triglycerides (Tg) and cholesterol (Chol) was changed. The drug has a stronger effect on triglyceride component of serum VIDLP and LDLP as compared with the corresponding cholesterol one, due to which its treatment is with better effect in IIB, IV and V type HLP. The decrease of cholesterol concentration in the separate types HLP differs in size and mode of induction. It is stronger in the mixed types HLP (II phi and V) and is due to decreased cholesterol content of LDLP and VLDLP, whereas in IIb type HLP - the serum concentrations of total Chol was decreased as well as of LDLP-Chol with a parallel increase of the levels of LVDLP-Chol and VLDLP-Tg. In IIA and V type HLP, serum concentration of HDLP-Chol is increased but insignificantly. Bezalip treatment changes the interlipoprotein index Ka (total Chol-HDLP-Chol/HDLP-Chol) in a favourable direction as regards the atherogenic risk, in all types HLP studied.
对34例（31例男性和3例女性）年龄在30至60岁、患有各种类型原发性高脂血症（IIA、IIB、IV和V型）的患者，进行了为期一个月的必降脂（每日600毫克）门诊治疗，研究其对血脂和脂蛋白的影响。治疗后发现，甘油三酯（Tg）和胆固醇（Chol）浓度升高的异常化趋势发生了改变。与相应的胆固醇成分相比，该药物对血清极低密度脂蛋白（VIDLP）和低密度脂蛋白（LDLP）中的甘油三酯成分作用更强，因此其治疗对IIB、IV和V型高脂血症效果更好。不同类型高脂血症中胆固醇浓度的降低在幅度和诱导方式上有所不同。在混合型高脂血症（II型和V型）中降低更为明显，这是由于低密度脂蛋白和极低密度脂蛋白中胆固醇含量降低所致，而在IIb型高脂血症中，总胆固醇的血清浓度以及低密度脂蛋白胆固醇均降低，同时极低密度脂蛋白胆固醇和极低密度脂蛋白甘油三酯水平平行升高。在IIA和V型高脂血症中，高密度脂蛋白胆固醇（HDLP-Chol）的血清浓度升高，但不显著。在必降脂治疗后，在所有研究的高脂血症类型中，脂蛋白间指数Ka（总胆固醇-高密度脂蛋白胆固醇/高密度脂蛋白胆固醇）朝着有利于降低动脉粥样硬化风险的方向改变。
