Barnick P, Stiller D, Glöckner R
Z Gesamte Inn Med. 1983 Sep 15;38(18):502-5.
It is reported on a 20-year-old male patient, in whom during the treatment of a streptococcal infection with ampicillin an exanthem and an acute interstitial nephritis with acute renal insufficiency appeared. The temporary connection between the application of the medicament and the occurrence of the clinical symptoms and the sensitization to ampicillin proved by the lymphocyte transformation test speak for an ampicillin-induced interstitial nephritis. The discontinuation of the treatment with ampicillin and the application of prednisolone led to a complete involution of the clinical picture. Since ampicillin is frequently used in the clinic one should take into consideration in the indication that possibly an acute renal insufficiency may appear due to an acute interstitial nephritis.
据报道，一名20岁男性患者在使用氨苄西林治疗链球菌感染期间出现了皮疹以及伴有急性肾功能不全的急性间质性肾炎。药物应用与临床症状出现之间的暂时关联以及淋巴细胞转化试验证实的对氨苄西林的致敏反应表明这是一例氨苄西林诱导的间质性肾炎。停用氨苄西林并应用泼尼松龙后，临床症状完全消退。由于氨苄西林在临床上经常使用，在用药指征方面应考虑到可能会因急性间质性肾炎而出现急性肾功能不全。
