Mende T
Z Gesamte Inn Med. 1983 Oct 1;38(19):201-4.
Nuclear-medical nephrological diagnostic methods increasingly obtain significance for the judgment of the function of the nephrological system on account of their non-invasive character and on account of improved technical possibilities which made their way into the nuclear-medical routine diagnostics. As to the technique a graduation is the result, beginning with examination methods which at present allow only a qualitative separated according to the sides judgment of the renal function (isotope nephrography and renoscintigraphy) up to the techniques which render possible quantitative evidence (renal sequence scintigraphy and determinations of the renal clearance). Using different nuclear pharmaceutics which underlie a different kinetics, blood supply as well as glomerular and tubular partial function can be demarcated from each other and simultaneously determined, respectively. The use of modern nuclear pharmaceutics, especially of 123I-hippurate from the Central Institute for Nuclear Research Rossendorf introduced into the diagnostics 1982 brings a further reduction of the as it is very low radiation exposure for the patient. The selection of the methods to be used and the nuclear pharmaceutics should always be performed depending on the clinical questioning. Isotope nephrography and renoscintigraphy are used in the preliminary diagnostics on suspicion of functional and morphologic changes of the kidneys. The renal sequence scintigraphy remains reserved to special questionings. It renders possible to establish according to the sides prerenal, intrarenal or postrenal disturbances of the functions of the kidneys globally as well as regionally and to perform a quantitative side-separated judgment of the function.(ABSTRACT TRUNCATED AT 250 WORDS)
核医学肾病诊断方法因其非侵入性以及技术可能性的提高而越来越多地应用于肾脏系统功能的判断,这些技术已进入核医学常规诊断。在技术方面,出现了一个梯度变化,从目前仅能根据肾脏功能进行定性单侧判断的检查方法(同位素肾造影和肾闪烁显像)到能够提供定量证据的技术(肾序列闪烁显像和肾清除率测定)。使用具有不同动力学的不同核药物,可以分别区分并同时测定血液供应以及肾小球和肾小管的部分功能。现代核药物的使用,特别是1982年引入诊断的来自罗斯多夫中央核研究所的123I - 马尿酸盐,由于对患者的辐射暴露非常低,进一步降低了辐射剂量。所使用的方法和核药物的选择应始终根据临床问题来进行。同位素肾造影和肾闪烁显像用于怀疑肾脏功能和形态改变的初步诊断。肾序列闪烁显像则用于特殊问题的诊断。它能够全面和局部地确定肾脏功能的肾前、肾内或肾后干扰,并进行功能的定量单侧判断。(摘要截选至250字)