先天性青光眼家族性传播的进一步分析。
Further analysis of familial transmission of congenital glaucoma.
作者信息
Demenais F
出版信息
Am J Hum Genet. 1983 Nov;35(6):1156-60.
Abstract
A re-analysis of familial transmission of congenital glaucoma is performed here using the unified model and considering, respectively, joint and conditional likelihoods. Whereas the familial aggregation of this malformation is consistent with the segregation of a recessive major gene and a high proportion of sporadic cases using conditional likelihood, this is rejected using joint likelihood. The difference in the results obtained using each of these two strategies is discussed.
摘要
本文使用统一模型，分别考虑联合似然和条件似然，对先天性青光眼的家族传播进行了重新分析。虽然这种畸形的家族聚集现象与隐性主基因的分离以及使用条件似然时高比例的散发病例一致，但使用联合似然时则被否定。讨论了使用这两种策略所获得结果的差异。
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