Lalouel J M, Morton N E
Hum Hered. 1981;31(5):312-21. doi: 10.1159/000153231.
Complex segregation analysis has been extended to apply to nuclear families and relatives outside the nuclear family that have led to its ascertainment. These individuals are referred to as pointers. The mixed model of Morton and MacLean has been modified to allow for a sex-linked major gene, mutation, and generational differences in multifactorial transmission for adults and children, respectively. The model and methods used in implementing it are described, as well as the rationale underlying this approach to analysis of pedigree data.
复杂分离分析已得到扩展，可应用于核心家庭以及导致其被确定的核心家庭之外的亲属。这些个体被称为指示者。莫顿和麦克林的混合模型已被修改，分别考虑了与性别相关的主基因、突变以及成人和儿童在多因素传递中的代际差异。文中描述了所使用的模型和实施方法，以及这种系谱数据分析方法的基本原理。
