Ferrández A
An Esp Pediatr. 1983 Sep;19 Suppl 18:101-8.
The beginning of puberty is caused by a decrease in high gonadostate sensibility to prepubertal levels of sexual steroids. What produces this change and timing is still unknown. However, it seems that the adrenal (delta-4 Androstenedione) as well as the pineal may play an important role. When it comes to that point, the hypothalamic LH-RH provokes a strong LH, FSH secretion; this triggers the gonadal sex-steroids production, which induces in turn the appearance of the secondary sex characteristics. Two years after the so called "mid growth spurt" begins the pubertal growth acceleration which reaches its peak to 2, 4 yrs later. The pubertal development is regulated by genetic factors. Bone age should be referred as a much better indicator than the chronological age.
青春期的开始是由于性腺对青春期前水平的性类固醇的高敏感性降低所致。是什么导致了这种变化以及变化的时间仍不清楚。然而，肾上腺（δ-4雄烯二酮）以及松果体似乎可能起重要作用。在这一点上，下丘脑促黄体生成素释放激素（LH-RH）会引发强烈的促黄体生成素（LH）和促卵泡生成素（FSH）分泌；这会触发性腺性类固醇的产生，进而诱导第二性征的出现。在所谓的“生长加速中期”开始两年后，青春期生长加速开始，并在2至4年后达到峰值。青春期发育受遗传因素调节。骨龄应被视为比实际年龄更好的指标。
