Hazen P G, Kark E C, Davis B R, Carney J F, Kurczynski E
Arch Dermatol. 1983 Dec;119(12):998-1002.
Two male infants manifested a complex of symptoms and signs that we believed represented a distinctive hypersensitivity disease, with features of acute febrile neutrophilic dermatosis and allergic vasculitis. Both were less than 1 year of age, and both acquired their disease during or after an upper respiratory illness. Each infant was initially seen with waxy and erythematous to slightly violaceous papules that enlarged to form plaques. The lesions developed at sites of trauma and were distributed on the trunk, face, and extremities. Both infants were febrile and had leukocytosis. On histopathologic examination, biopsy specimens taken from the lesions demonstrated a pronounced dermal infiltration of polymorphonuclear leukocytes. These lesions responded to treatment with prednisone and topical fluorinated corticosteroids, healed with scarring, and recurred after initial improvement.
两名男婴表现出一系列症状和体征，我们认为这些症状和体征代表一种独特的超敏反应性疾病，具有急性发热性嗜中性皮病和过敏性血管炎的特征。两人均未满1岁，且均在上呼吸道疾病期间或之后患病。每名婴儿最初就诊时均有蜡样、红斑至轻度紫蓝色丘疹，这些丘疹逐渐增大形成斑块。病变发生于创伤部位，分布于躯干、面部和四肢。两名婴儿均发热且有白细胞增多。组织病理学检查显示，取自病变部位的活检标本有多形核白细胞显著的真皮浸润。这些病变对泼尼松和外用氟化皮质类固醇治疗有反应，愈合后留有瘢痕，且在最初改善后复发。
