去甲肾上腺素能系统在4-氨基吡啶对大鼠的抗伤害感受作用中的角色。

The role of a noradrenergic system in the antinociceptive effects of 4-aminopyridine in the rat.

作者信息

Rupreht J, Dzoljic M R

出版信息

Arch Int Pharmacodyn Ther. 1983 Oct;265(2):203-10.

Abstract

Antinociceptive effects of physostigmine and 4-aminopyridine after i.p. administration were studied in rats according to the Randall-Selitto nociception method. The antinociceptive action of physostigmine was not significantly influenced by atropine, naloxone or alpha-methyl-p-tyrosine. The antinociceptive action of 4-aminopyridine was also unaffected by simultaneous administration of atropine, naloxone or pretreatment by DL-p-chlorophenylalanine. However, 4-aminopyridine was without antinociceptive effect in rats pretreated with alpha-methyl-p-tyrosine. It is suggested that the antinociceptive action of 4-aminopyridine is mediated by a noradrenergic system.

摘要

根据兰德尔-塞利托疼痛感受法，研究了大鼠腹腔注射毒扁豆碱和4-氨基吡啶后的镇痛作用。毒扁豆碱的镇痛作用不受阿托品、纳洛酮或α-甲基-p-酪氨酸的显著影响。同时给予阿托品、纳洛酮或用DL-p-氯苯丙氨酸预处理，4-氨基吡啶的镇痛作用也不受影响。然而，α-甲基-p-酪氨酸预处理的大鼠中，4-氨基吡啶没有镇痛作用。提示4-氨基吡啶的镇痛作用是由去甲肾上腺素能系统介导的。