Terracio L, Kubicek W G
Acta Anat (Basel). 1978;101(4):372-9. doi: 10.1159/000144988.
The effectiveness of beta-histine-HCL in modifying the size of developing myocardial infarcts was tested in the surgically ligated dog. Branches of the left coronary artery were ligated and a 6-hour continuous intravenous infusion of 0.24 mg/kg/min of beta-histine was administered from 0 to 120 min after ligation. The effect of this treatment was evaluated histologically in studies on acute ischemia by the use of the hematoxylin-basic fuchsin-picric acid stain for early myocardial ischemia. The treatment was also evaluated grossly in a study on chronic ischemia where the dogs were permitted to survive for 30 days before sacrifice. In these experiments the size of infarcts found in the beta-histine-treated animals was compared with those found in the saline controls. Both studies showed that the control ligations produced a large uniform area of ischemia or infarction that was greatly reduced or prevented by immediate treatment with beta-histine. Also, beta-histine was capable of significantly reducing the size of developing infarcts for up to 120 min after ligation.
在手术结扎的犬身上测试了盐酸倍他司汀改变正在形成的心肌梗死面积的有效性。结扎左冠状动脉分支，并在结扎后0至120分钟内以0.24毫克/千克/分钟的剂量持续静脉输注盐酸倍他司汀6小时。在急性缺血研究中，通过使用苏木精-碱性品红-苦味酸染色来评估早期心肌缺血，从组织学角度评价这种治疗的效果。在慢性缺血研究中，在处死前让犬存活30天，也从大体上对治疗效果进行了评估。在这些实验中，将盐酸倍他司汀治疗组动物的梗死面积与生理盐水对照组动物的梗死面积进行了比较。两项研究均表明，对照结扎产生了大面积均匀的缺血或梗死区域，而立即用盐酸倍他司汀治疗可使其大大减少或得到预防。此外，盐酸倍他司汀能够在结扎后长达120分钟内显著减小正在形成的梗死面积。
