Tsai L Y, Nasrallah H A, Jacoby C G
Arch Gen Psychiatry. 1983 Dec;40(12):1286-9. doi: 10.1001/archpsyc.1983.01790110028006.
A major reason for reassessing hemispheric asymmetries in schizophrenics by computed tomography is the methodologic shortcomings of previously published measurement techniques. We used completely blind measurements, multiple measurements performed by two independent examiners of each region of the brain, and an SE of measurement with a confidence level of P less than .01 to define significant asymmetry. The frequency of reversed occipital asymmetry was significantly higher in the 36 schizophrenic than in the 18 manic right-handed male patients. Furthermore, when all of the previously published techniques were applied to these patients, the frequency of such a reversal was consistently higher in the schizophrenic than in the manic group. Further investigation of hemispheric asymmetries in schizophrenics is warranted.
通过计算机断层扫描重新评估精神分裂症患者半球不对称性的一个主要原因是先前发表的测量技术存在方法学上的缺陷。我们采用了完全盲法测量，由两名独立检查者对大脑每个区域进行多次测量，并使用置信水平P小于0.01的测量标准误来定义显著不对称性。36例精神分裂症患者枕叶不对称反转的频率显著高于18例躁狂症右利手男性患者。此外，当将所有先前发表的技术应用于这些患者时，精神分裂症患者这种反转的频率始终高于躁狂症组。有必要对精神分裂症患者的半球不对称性进行进一步研究。
