The sensitive period for ototoxicity of kanamycin in mice: morphological evidence.

The ototoxicity of kanamycin was investigated in mice treated with the drug either from 6 to 9, 10 to 13, or 15 to 18 days of age. The results showed extensive damage to the outer-hair-cell (OHC) receptors of the cochlea in the 10-13-day group; some less severe damage to the OHC was found in the 6-9-day group, and little damage was observed in the 15-18 day group. The present finding is consistent with the view that the mouse cochlea is most vulnerable to the ototoxic effect of kanamycin during the period of its rapid development, i.e., between 10 and 13 days of age.