Watson A D, Middleton D J, Ilkiw J E
Aust Vet J. 1983 Oct;60(10):305-7. doi: 10.1111/j.1751-0813.1983.tb02815.x.
A 5-year-old male Bedlington terrier was found to have haemoglobinuria from intravascular haemolysis. The owners reported also recent vomiting, occasional diarrhoea, reduced activity and increased drinking and urination. A diagnosis of inherited copper storage disease, as previously described in this breed, was established by demonstrating characteristic light and electron microscopic changes and copper content of 7, 717 micrograms/g in biopsied liver. Treatment by chelation with d-penicillamine and a low copper diet was instituted and the dog remains well 10 months later. Intravascular haemolysis is rare in dogs and an uncommon finding in Bedlington terriers with copper storage disease.
一只5岁的雄性贝德灵顿梗犬被发现因血管内溶血而出现血红蛋白尿。主人还报告称，该犬近期有呕吐、偶尔腹泻、活动减少以及饮水和排尿增加的症状。通过活检肝脏显示出特征性的光镜和电镜变化以及铜含量为7717微克/克，确诊为该品种先前描述的遗传性铜贮积病。采用青霉胺螯合疗法和低铜饮食进行治疗，10个月后该犬状况良好。血管内溶血在犬类中较为罕见，在患有铜贮积病的贝德灵顿梗犬中也是不常见的表现。
