Fenton M R, Burke J P
Biochem Med. 1983 Oct;30(2):196-205. doi: 10.1016/0006-2944(83)90086-8.
beta-Glucuronidase activity increased in the serum of BALB/c mice during the growth of the IgM-secreting plasmacytoma, TEPC-183. The increase appeared to correlate with tumor burden. The beta-glucuronidase activity in tissue homogenates of spleen, liver, and kidney from tumor-bearing mice also increased significantly compared to the levels found in corresponding tissues from normal control mice. Assays of lysosomal and microsomal fractions from livers of TEPC-bearing mice indicated that approximately 70% of the enzyme activity was associated with the lysosomal fraction and the remainder with the microsomal fraction. A similar distribution was found in homogenates prepared from the plasmacytoma itself. In contrast to this the beta-glucuronidase activity in livers from normal BALB/c mice is nearly equally distributed between lysosomal and microsomal fractions.
在分泌IgM的浆细胞瘤TEPC - 183生长期间，BALB/c小鼠血清中的β - 葡萄糖醛酸酶活性增加。这种增加似乎与肿瘤负荷相关。与正常对照小鼠相应组织中的水平相比，荷瘤小鼠脾脏、肝脏和肾脏组织匀浆中的β - 葡萄糖醛酸酶活性也显著增加。对荷TEPC小鼠肝脏的溶酶体和微粒体部分进行分析表明，约70%的酶活性与溶酶体部分相关，其余与微粒体部分相关。在由浆细胞瘤本身制备的匀浆中也发现了类似的分布。与此相反，正常BALB/c小鼠肝脏中的β - 葡萄糖醛酸酶活性在溶酶体和微粒体部分之间几乎平均分布。
