Grammer R T, Fukumi H, Inagami T, Misono K S
Biochem Biophys Res Commun. 1983 Oct 31;116(2):696-703. doi: 10.1016/0006-291x(83)90581-8.
The atrial natriuretic activity of rat heart has been found to exist in multiple forms. One of these factors has been purified to apparent homogeneity by a combination of gel filtration and high pressure liquid chromatography in two different systems and its amino acid composition determined. The purified active peptide is shown to have a molecular weight of approximately 3800. In addition, the vasorelaxant activity of rat atrium has been purified and found to co-chromatograph with the natriuretic activity in all chromatographic systems employed. Thus, the vasorelaxant activity resides in the natriuretic factor. The existence of this new multifunctional peptide implies a higher level of complexity for cardiovascular control of blood volume and pressure.
已发现大鼠心脏的心房利钠活性以多种形式存在。其中一种因子通过在两种不同系统中结合凝胶过滤和高压液相色谱法纯化至表观均一，并测定了其氨基酸组成。纯化的活性肽显示分子量约为3800。此外，大鼠心房的血管舒张活性已被纯化，并发现在所有使用的色谱系统中与利钠活性共色谱。因此，血管舒张活性存在于利钠因子中。这种新的多功能肽的存在意味着心血管对血容量和压力的控制具有更高水平的复杂性。
