鹅去氧胆酸 -3- 硫酸盐。在大鼠和仓鼠体内的代谢与排泄以及对肝脏转运系统的影响。

Chenodeoxycholic acid-3-sulfate. Metabolism and excretion in the rat and hamster and effects on hepatic transport systems.

作者信息

Eng C, Javitt N B

出版信息

Biochem Pharmacol. 1983 Dec 1;32(23):3555-8. doi: 10.1016/0006-2952(83)90302-7.

Abstract

The metabolism and excretion of chenodeoxycholic acid-3-sulfate were determined in rats and hamsters. Constant intravenous infusions of 1, 2, and 3 mumoles/min in rats gave a maximum excretion in bile of 1.25 mumoles/min. Simultaneous infusions of sodium taurocholate at 2.0 mumoles/min and sulfobromophthalein at 0.2 mumole/min had no effects on the maximum excretion rate of chenodeoxycholic acid-3-sulfate. However, the bile acid ester sulfate caused a dose-related reduction in the excretion rate of BSP without affecting bile acid excretion rate and without a reduction in total bile flow. Chromatographic analysis of ester sulfate, a bile acid recovered in bile and urine, indicated that more than 95% had not undergone further metabolic transformation.

摘要

在大鼠和仓鼠体内测定了鹅去氧胆酸 -3- 硫酸盐的代谢和排泄情况。在大鼠中以每分钟 1、2 和 3 微摩尔的速率持续静脉输注，胆汁中的最大排泄量为每分钟 1.25 微摩尔。同时以每分钟 2.0 微摩尔的速率输注牛磺胆酸钠和以每分钟 0.2 微摩尔的速率输注磺溴酞钠，对鹅去氧胆酸 -3- 硫酸盐的最大排泄率没有影响。然而，胆汁酸酯硫酸盐导致磺溴酞钠的排泄率呈剂量相关降低，而不影响胆汁酸排泄率且总胆汁流量不降低。对胆汁和尿液中回收的胆汁酸酯硫酸盐进行色谱分析表明，超过 95% 未发生进一步的代谢转化。