Wicke W, Welleschik B, Firbas W, Sinzinger H
Acta Otolaryngol. 1978 May-Jun;85(5-6):360-2.
The neuronal density in the spiral ganglion was investigated in normal and in streptomycin-intoxicated guinea pigs. Streptomycin was administered in a dose of 250 mg/kg for 21 days. 6 weeks after the streptomycin exposure a histological examination revealed a decrease in ganglion cell density in the spiral ganglion, with maximum loss in the apical portion of the ganglion. As mechanisms of the ototoxic effect, a secondary degeneration of spiral ganglion cells after hair cell loss or a primary neurotoxic degeneration are discussed.
研究了正常和链霉素中毒豚鼠螺旋神经节中的神经元密度。以250mg/kg的剂量给予链霉素，持续21天。链霉素暴露6周后，组织学检查显示螺旋神经节中神经节细胞密度降低，神经节顶端部分损失最大。作为耳毒性作用的机制，讨论了毛细胞丧失后螺旋神经节细胞的继发性变性或原发性神经毒性变性。
