Sugano N
Biol Cybern. 1983;49(1):55-61. doi: 10.1007/BF00336928.
The effects of doublet impulse sequences of the excitatory motor axon on the movement of the claw opener muscles in the crayfish were examined. The excitatory motor axon was stimulated electrically with various patterns of doublet impulse sequences generated by a digital computer. Doublet impulse sequences of stimulation produced a larger sustained movement than an uniform impulse sequences at the same mean rate of stimulation. The movement was largest when the interval between the impulses of a doublet was about 5 ms. This interval generated a movement amplitude 25% greater than that for the uniform impulse sequence. A simple model was formulated to stimulate the neuromuscular synapse of the claw opener muscle. The relationship between stimulation sequences with alternating long and short intervals and responses (firing probabilities) of the neuromuscular synapse at the same mean rate was investigated. The responses was classified into two typical types which are noneffective Type I and effective Type II to the absolute refractory period (ARP). The characteristics which are larger responses with short intervals in Type I and reduction of responses in the ARP region of Type II formed a plateau peak of the experimental results. By incorporating the reduction of end-plate potential (EPP) as a property of nonlinear rule for temporal summation into the model, it was shown that Type I response is maximal with a plateau peak at short interval, agreeing well with the experimental results from the claw opener muscles.
研究了兴奋性运动轴突的双脉冲序列对小龙虾爪张开肌运动的影响。用数字计算机产生的各种双脉冲序列模式对兴奋性运动轴突进行电刺激。在相同的平均刺激频率下，双脉冲序列刺激产生的持续运动比均匀脉冲序列更大。当双脉冲的脉冲间隔约为5毫秒时，运动最大。这个间隔产生的运动幅度比均匀脉冲序列大25%。建立了一个简单的模型来模拟爪张开肌的神经肌肉突触。研究了具有交替长短间隔的刺激序列与相同平均频率下神经肌肉突触反应（发放概率）之间的关系。根据绝对不应期（ARP），反应分为两种典型类型，即无效的I型和有效的II型。I型中短间隔时反应较大以及II型在ARP区域反应降低的特征形成了实验结果的一个平台峰。通过将终板电位（EPP）的降低作为时间总和非线性规则的一个特性纳入模型，结果表明I型反应在短间隔时具有最大的平台峰，与爪张开肌的实验结果非常吻合。
