Brumm P
Br J Radiol. 1983 Dec;56(672):957-62. doi: 10.1259/0007-1285-56-672-957.
The nominal standard dose depends mainly upon the skin reaction, the field size, and the location. In particular, different degrees of skin reaction cause variations in the "tolerance dose" up to a factor of 2. The influence of these parameters must be taken into account carefully in order to attain valid conclusions. The NSD concept has been verified by re-evaluation of Strandqvist's investigation. An exponent of 0.28 +/- 0.04 has been calculated, which is at the lower limit of Ellis' value (0.35). The use of the NSD formula may fail for radiation regimens which are not bound to skin reaction. Several radiation schemes in the treatment of lung cancer exhibit worse tumour control though NSD values are higher. For this a strong correlation between survival rate and fractionation frequency has been found.
标称标准剂量主要取决于皮肤反应、照射野大小和部位。特别是，不同程度的皮肤反应会使“耐受剂量”变化高达2倍。为了得出有效的结论，必须仔细考虑这些参数的影响。NSD概念已通过对斯特兰德奎斯特研究的重新评估得到验证。已计算出指数为0.28±0.04，这处于埃利斯值（0.35）的下限。对于不受皮肤反应限制的放疗方案，NSD公式可能不适用。尽管NSD值较高，但肺癌治疗中的几种放疗方案显示出较差的肿瘤控制效果。为此，已发现生存率与分割频率之间存在很强的相关性。
