Daculsi G, Faure G, Kerebel B
Calcif Tissue Int. 1983 Sep;35(6):723-7. doi: 10.1007/BF02405113.
This paper reports the study of a subcutaneous heterotopic calcification from a patient with Thibierge-Weissenbach's syndrome, a type of creeping scleroderma included in the CRST syndrome. These local deposits, whose origin is still unknown, are commonly considered to be a classic apatite phase. Using SEM, high resolution TEM, electron diffraction, infrared spectrometry, and SEM and TEM microanalysis, it is demonstrated that this material is highly heterogeneous and appears in a nonstoichiometric, carbonated, calcium ion-deficient apatitic solid phase. Our study shows the coexistence of dense globules presenting an ill-organized, more or less amorphous phase (ACP) or microcrystalline (OCP, beta tricalcium phosphate), with scattered apatite crystals, and of interglobular apatite crystals with a good cristallinity.
本文报道了对一名患有蒂比耶热 - 魏森巴赫综合征（一种包含在CRST综合征中的进行性硬皮病）患者皮下异位钙化的研究。这些局部沉积物的起源尚不清楚，通常被认为是典型的磷灰石相。通过扫描电子显微镜（SEM）、高分辨率透射电子显微镜（TEM）、电子衍射、红外光谱以及SEM和TEM微分析表明，这种物质高度不均匀，呈现出非化学计量的、含碳酸根的、钙离子缺乏的磷灰石固相。我们的研究表明，存在密集的小球体，呈现出组织不良、或多或少无定形的相（无定形磷酸钙，ACP）或微晶相（八钙磷酸钙，OCP，β - 磷酸三钙），伴有分散的磷灰石晶体，以及球间具有良好结晶度的磷灰石晶体。
