Ishinishi N, Yamamoto A, Hisanaga A, Inamasu T
Cancer Lett. 1983 Dec;21(2):141-7. doi: 10.1016/0304-3835(83)90200-8.
The tumorigenicity of arsenic trioxide was investigated in female Syrian golden hamsters which were given a total of 5.25 mg or 3.75 mg as arsenic by intratracheal instillations once a week. As controls, hamsters were treated with the vehicle, phosphate buffer solution. During the total life span, 3 lung adenomas were manifested in 10 hamsters or 2 lung adenomas in another 20 hamsters after 15 instillations of arsenic, while no lung tumor was detected among 35 hamsters in 2 control groups. The results show that arsenic trioxide is tumorigenic to the lung of Syrian golden hamsters.
研究了三氧化二砷对雌性叙利亚金仓鼠的致瘤性，每周通过气管内滴注给予仓鼠总量为5.25毫克或3.75毫克的砷。作为对照，仓鼠用赋形剂磷酸缓冲溶液进行处理。在整个生命周期中，10只仓鼠在滴注15次砷后出现了3个肺腺瘤，另外20只仓鼠出现了2个肺腺瘤，而2个对照组的35只仓鼠中未检测到肺肿瘤。结果表明，三氧化二砷对叙利亚金仓鼠的肺部具有致瘤性。
