Slotman G J, Machiedo G W, Novak R T, Rush B F
Circ Shock. 1983;11(3):187-94.
The effect of profound hypercapnia on acute hypoxic respiratory failure is evaluated. Eight dogs were subjected to oleic acid-induced acute respiratory failure. Four dogs were ventilated normally, and four dogs were made hypercapneic by rebreathing exhaled CO2. In the hypercapneic animals, heart rate and alveolar-arterial oxygen difference were significantly lower than in normocapneic animals, while mixed venous O2 cardiac index, oxygen delivery index, stroke volume index, and left ventricular stroke work were significantly higher. Mean arterial pressure was maintained at preinjury levels. Pulmonary and systemic vascular resistance increased in both experimental groups. There was no significant difference between groups for gravimetric determination of lung water. Cardiopulmonary performance in acute respiratory failure is improved with hypercapnia. This may be related to CO2-induced catecholamine release.
评估深度高碳酸血症对急性低氧性呼吸衰竭的影响。八只犬接受油酸诱导的急性呼吸衰竭。四只犬正常通气，四只犬通过重新吸入呼出的二氧化碳造成高碳酸血症。在高碳酸血症动物中，心率和肺泡 - 动脉氧分压差显著低于正常碳酸血症动物，而混合静脉血氧含量、心排血指数、氧输送指数、每搏量指数和左心室每搏功显著更高。平均动脉压维持在损伤前水平。两个实验组的肺血管阻力和体循环血管阻力均增加。两组间肺水重量测定无显著差异。高碳酸血症可改善急性呼吸衰竭时的心肺功能。这可能与二氧化碳诱导的儿茶酚胺释放有关。
