Slotman G J, Machiedo G W, Casey K F, Novak R T, Rush B F
Adv Shock Res. 1980;3:283-9.
The hemodynamic effect of prostaglandin E1 (PGE1) on acute respiratory failure is investigated. Eight adult mongrel dogs were subjected to oleic acid-induced acute respiratory failure. Four dogs received PGE1 intravenously one hour after oleic acid injection, and four received an equal volume of saline. Cardiac output, arterial PO2 and alveolar-arterial oxygen difference decreased significantly in the saline-treated animals, and systemic vascular resistance increased. These parameters were maintained in the PGE1 group, and stroke volume and arterial-venous oxygen difference were improved. Pulmonary vascular resistance increased in both groups. This beneficial effect of PGE1 in acute respiratory failure may be related to maintenance of hemodynamics and pulmonary gas exchange and to improved tissue oxygenation.
研究了前列腺素E1（PGE1）对急性呼吸衰竭的血流动力学效应。八只成年杂种犬接受油酸诱导的急性呼吸衰竭。四只犬在注射油酸一小时后静脉注射PGE1，另外四只犬接受等体积的生理盐水。生理盐水处理组动物的心输出量、动脉血氧分压和肺泡-动脉血氧分压差显著降低，全身血管阻力增加。PGE1组这些参数得以维持，且每搏输出量和动静脉血氧分压差得到改善。两组的肺血管阻力均增加。PGE1对急性呼吸衰竭的这种有益作用可能与血流动力学和肺气体交换的维持以及组织氧合的改善有关。
