Hock C E, Su J Y, Lefer A M
Circ Shock. 1983;11(3):211-6.
Anisodamine, an alkaloid originally extracted from the Chinese herb Anisodus tanguticus, has been reported to possess beneficial actions in septic, superior mesenteric artery occlusion, and hemorrhagic shock. We have investigated its actions in traumatic shock in rats. Anisodamine (2.5 mg/kg) increased survival time from 1.4 +/- 0.2 h to 3.1 +/- 0.3 h (P less than 0.001) in traumatized rats with 50% of the drug-treated animals surviving at least 3.5 h. Drug treatment had no significant effect on plasma cathepsin D activity (12.0 +/- 2.3 vs 10.4 +/- 1.7; vehicle- vs drug-treated, respectively). However, plasma myocardial depressant factor accumulation was significantly blunted by anisodamine, 62 +/- 5 vs 41 +/- 5 U/ml (P less than 0.02), indicating that prevention of MDF formation may be one protective mechanism of this substance.
山莨菪碱是一种最初从中药唐古特山莨菪中提取的生物碱，据报道它在脓毒症、肠系膜上动脉闭塞和失血性休克中具有有益作用。我们研究了它在大鼠创伤性休克中的作用。山莨菪碱（2.5毫克/千克）使创伤大鼠的存活时间从1.4±0.2小时增加到3.1±0.3小时（P<0.001），50%接受药物治疗的动物至少存活3.5小时。药物治疗对血浆组织蛋白酶D活性无显著影响（分别为12.0±2.3和10.4±1.7；载体处理组与药物处理组）。然而，山莨菪碱显著抑制了血浆心肌抑制因子的蓄积，分别为62±5和41±5 U/ml（P<0.02），这表明预防MDF形成可能是该物质的一种保护机制。
