Mehlman M A
Environ Health Perspect. 1983 Oct;52:261-6. doi: 10.1289/ehp.8352261.
The ambient air quality standard established in 1973 is 0.03 ppm annual average for sulfur dioxide and 0.075 mg/m3 for particulates. It is now generally believed that the toxicity of sulfur oxides in ambient air is significantly influenced by the coincident presence of particulates. Inhalation of 1 ppm of sulfur dioxide for 2 hr may produce alterations in pulmonary ventilatory function, both in normal and asthmatic subjects. Effects obtained at 0.5 ppm of sulfur dioxide are controversial and of questionable biological significance. No clear evidence exists that sulfur dioxide or bisulfite causes mutagenicity in mammals, and it is concluded from a variety of animal experiments that long-term exposure to sulfur dioxide alone does not cause cancer.
1973年制定的环境空气质量标准为：二氧化硫年平均浓度0.03 ppm，颗粒物浓度0.075 mg/m³。现在普遍认为，环境空气中硫氧化物的毒性受颗粒物同时存在的显著影响。无论是正常受试者还是哮喘患者，吸入1 ppm二氧化硫2小时都可能导致肺通气功能改变。在0.5 ppm二氧化硫浓度下所获得的影响存在争议，其生物学意义也值得怀疑。没有明确证据表明二氧化硫或亚硫酸氢盐会在哺乳动物中引起致突变性，并且从各种动物实验得出的结论是，长期单独接触二氧化硫不会致癌。
