Neijens H J, Kerrebijn K F
Eur J Respir Dis. 1983 Nov;64(8):591-7.
In a previous study 30 asthmatic children with positive skin tests to cat dander, had bronchial challenge tests with histamine and antigen, quantitative skin tests with cat dander, and measurements of serum-specific IgE concentrations (first study). When bronchial responsiveness (BR) was found to be changed in the course of a follow-up period, these patients (4 had a decrease and 4 an increase in BR), as well as 2 patients with an unchanged BR, were restudied (second study). An increase in BR was associated with a change from a negative to a positive reaction to the inhalation of allergen. The patients in whom BR decreased, showed a less severe inhalation reaction to allergen in the second than in the first study. The inhalation reaction was not changed in the patients with an unchanged BR. The variation of allergen-induced bronchial obstruction could not be related to a change in sensitization to the allergen or in the baseline lung function, and is, thus, probably associated with the variation in BR.
在之前的一项研究中，30名对猫毛屑皮肤试验呈阳性的哮喘儿童接受了组胺和抗原支气管激发试验、猫毛屑定量皮肤试验以及血清特异性IgE浓度测定（第一项研究）。当在随访期间发现支气管反应性（BR）发生变化时，对这些患者（4例BR降低，4例BR升高）以及2例BR无变化的患者进行了重新研究（第二项研究）。BR升高与吸入变应原的反应从阴性变为阳性有关。BR降低的患者在第二项研究中对变应原的吸入反应比第一项研究中轻。BR无变化的患者吸入反应未改变。变应原诱导的支气管阻塞的变化与对变应原的致敏性变化或基线肺功能变化无关，因此，可能与BR的变化有关。
