自我刺激以及经口或腹腔注射酒精。

Self-stimulation and alcohol administered orally or intraperitoneally.

作者信息

De Witte P, Bada M F

出版信息

Exp Neurol. 1983 Dec;82(3):675-82. doi: 10.1016/0014-4886(83)90089-4.

Abstract

The relationships in rats between the reinforcing value of electrical self-stimulation of the brain and varying concentrations of ethanol in the drinking solution (from 5 to 40% v/v alcohol) or in i.p. injections (0.3, 0.6, 1.2, and 1.8 g/kg of alcohol) were studied. The reinforcing value of brain stimulation was quantified using the total time spent in self-stimulation and the number of bar pressings. Results showed that the relationships depended on the ethanol concentration, the degree of reinforcement of the brain stimulation, and the route of administration of the ethanol solution. Particularly, a small dosage injected intraperitoneally or ingested orally accentuated the reward produced by an electrical brain stimulation when the self-stimulation performance was still high. On the contrary, a large dosage of alcohol always dramatically depressed the self-stimulation performance.

摘要

研究了大鼠大脑电刺激的强化值与饮用溶液中不同浓度乙醇（酒精体积分数从5%到40%）或腹腔注射（0.3、0.6、1.2和1.8 g/kg酒精）之间的关系。使用自我刺激所花费的总时间和压杆次数对大脑刺激的强化值进行量化。结果表明，这些关系取决于乙醇浓度、大脑刺激的强化程度以及乙醇溶液的给药途径。特别是，当自我刺激表现仍然很高时，腹腔注射或口服小剂量乙醇会增强大脑电刺激产生的奖赏作用。相反，大剂量酒精总是会显著降低自我刺激表现。